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  • Informatics colloquium 27. 3. Case studies in multimodal biomarker discovery

    Informatics colloquium 27. 3. 2018, 14:00 lecture hall D2 Ing. Vlad Popovici, M.Sc., Ph.D., PřF MU Abstract: High throughput genomic revolution started almost twenty years ago with the first in-house printed DNA chips. Since then, various technologies evolved, allowing the interrogation of the whole (human) genome, proteome, metabolome, etc., all producing large amounts of data. Bioinformatics tools and methods evolved to account for all these data modalities with the current bottleneck being the integration of these perspectives into a more comprehensive picture. In parallel and completely independent of bioinformatics, digital pathology also witnessed significant advances fuelled mostly by technological developments: slide scanners and computational infrastructure. However, both “classical” bioinformatics and digital pathology/bioimaging are often used to investigate the same biological phenomenon. It is, therefore, natural to attempt to combine these two seemingly incompatible fields with the hope of unveiling new connections between them. In this talk we will look at three examples of jointly mining the transcriptome and the histopathology images in the context of breast and colon cancers. We will also discuss the computational challenges one faces when working with these data.

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