Informatics colloquium 27. 3. Case studies in multimodal biomarker discovery
Informatics colloquium 27. 3. 2018, 14:00 lecture hall D2
Ing. Vlad Popovici, M.Sc., Ph.D., PřF MU
Abstract: High throughput genomic revolution started almost twenty years ago
with the first in-house printed DNA chips. Since then, various technologies
evolved, allowing the interrogation of the whole (human) genome, proteome,
metabolome, etc., all producing large amounts of data. Bioinformatics tools and
methods evolved to account for all these data modalities with the current
bottleneck being the integration of these perspectives into a more comprehensive
picture. In parallel and completely independent of bioinformatics, digital
pathology also witnessed significant advances fuelled mostly by technological
developments: slide scanners and computational infrastructure. However, both
“classical” bioinformatics and digital pathology/bioimaging are often used to
investigate the same biological phenomenon. It is, therefore, natural to attempt
to combine these two seemingly incompatible fields with the hope of unveiling
new connections between them. In this talk we will look at three examples of
jointly mining the transcriptome and the histopathology images in the context of
breast and colon cancers. We will also discuss the computational challenges one
faces when working with these data.