Seminars@FI: Prajna Hebbar: Comparative Annotation Toolkit 2.0: Generating high-quality gene annotations on complete primate genomes and human pangenomes to study gene evolution
Zveme vás na přednášku Prajny Hebbar z Fakulty biomolekulárního inženýrství University of California Santa Cruz.
Téma: Comparative Annotation Toolkit 2.0: Generating high-quality gene annotations on complete primate genomes and human pangenomes to study gene evolution
Kdy: 22. září 2025 v 16:00 hod.
Kde: místnost KYPO, Fakulta informatiky MU, Botanická 68a, Brno
Anotace: Vertebrate genomics is heading into an era where the release of hundreds of new reference genomes a year is going to be the norm. If we are to effectively engage with the new biology, we need to be able to annotate genes on these genomes accurately and efficiently. Unfortunately, the current state of gene annotation software requires the use of multiple tools and hours of manual curation. In order to remedy this, I am working on CAT2.0, an improved version of the Comparative Annotation Toolkit. CAT2.0 performs both evidence-based and de novo gene annotation. It can simultaneously annotate many closely related genomes using an annotated reference genome while incorporating information like RNA-seq/Iso-seq data or transcripts and protein homology. CAT2.0 has been used to annotate genomes for several large-scale genome projects, such as the T2T Primates Project, Human Pangenome, and Vertebrate Genomes Projects. In my talk, I will present current developments in the tool and also some results from annotating the human pangenome and a few complete primate genomes.
Bio: Prajna Hebbar is a PhD student in the Department of Biomolecular Engineering at the University of California Santa Cruz under the supervision of Dr Benedict Paten. She is extremely interested in developing methods for comparative and pan-genomics, with a focus on gene annotation. Her most recent efforts have been towards annotating the human pangenome and building a complete human transcriptome. She is also working to assemble and annotate the complete T2T genome of the common marmoset. She has previously played a key role in the T2T Primates project.
Následující den pak proběhne ve stejný čas přednáška Prajny Hebbar na téma Complete Genome Assemblies for the Common Marmoset.
